دانشگاه علوم پزشکی و خدمات بهداشتی درمانی استان فارس
Received 2018 May 03; Revised 2018 October 13; Accepted 2018 October 25.
Context: Dysmenorrhea is a common problem in women.
Objectives: This study aimed to summarize the results of all relevant clinical trials to draw a conclusion regarding the effect of
Foeniculum vulgare on primary dysmenorrhea (PD).
Methods: In this study, we searched 19 databases (including Medline/PubMed, Scopus, ISIWeb of Science) for the effects of Foeniculum
vulgare on primary dysmenorrhea up to November 2016. The reference lists of the reviews and related articles were consulted to
identify eligible articles. Studies investigating combinations of fennel and other products, without a control group, addressing premenstrual
syndrome (PMS) and bleeding as the primary outcomes, and not being a randomized clinical trial (RCT) were excluded.
A meta-analysis was performed to obtain a pooled estimate of effectiveness. The methodological quality was assessed using the
modified Jadad scale. The registration number of this study is 95-01-65-11733.
Results: Our search identified nine relevant articles for inclusion. The meta-analysis showed favorable effects of Foeniculum vulgare
on primary dysmenorrhea for fixed effect (n = 727, OR = 0.573, 95% CI: 0.414 to 0.793, P = 0.001) and random effect (n = 727, OR = 0.141,
95% CI: 0.027 to 0.742, P = 0.021). The analysis also revealed a remarked heterogeneity (Q value = 198.318, P = 0.000, I2 = 95.96,  2 =
6.065).
Conclusions:We found that the fennel extract is effective for primary dysmenorrhea. However, due to the heterogeneity of various
findings,wewere unable tofindthe effective dosageandconcentration of this herbal medicine.
نویسنده:
تعداد بازدید:
55
تاریخ:
1398/09/10
کلیه حقوق این پایگاه متعلق به مرکز تحقیقات طب سنتی و تاریخ پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی درمانی استان فارس می باشد.
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